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Polyglutamine Binding Protein-1(PQBP!) is encoded by a gene present on X chromosome. It is an important protein in terms of its role in Neuro-degeneration which leads to X-Linked Mental Retardation. It is a compelling hypothesis that proteins which play role in euro-degeneration induce apoptosis. Various evidence has been found to support of this as over expression of this protein in transgenic mice and in vitro samples have induced apoptosis and late motor neurone development. We speculate that this protein might also play a significant role in cancer cell proliferation. Phenotypic studies done on DU145 cells of over expression and knock down shows that PQBP1 inhibits cell proliferation. Though in vitro assays of over expression and knockdown of PQBP1 in prostate Cancer cell line DU145, it down regulate protein involved in inducing cell proliferation like Pin1, C-Jun, CMyc, phosphorus-cMyc, NF-KB and P38 Moreover it down regulate antiapoptotic protein Bcl-xL after over expression of PQBP1. Hence it can be concluded that PQBP1 can control cell proliferation and induce apoptosis, which are characteristic of tutor suppressor genes. When we overexposed PQBP1 colony size of cells have been inhibited. PQBP1 could be a novel drug target for the treatment of cancer, could be developed as cancer biomarker for future therapy.
