Anurag Adhikari is currently working on the functional aspect of human adaptive immunity. His research utilizes the polyclonal antibody Fc effector function to understand the role of humoral immunity during viral diseases so as to understand how it primes innate immunity early in the infection cascade. He has developed the antibody assay platform to understand Fc effector function of antibodies produced during Hepatitis C virus and SARS CoV-2 infection. He is currently adapting the assay of antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent neutralization (ADN) to understand HIV-1 pathogenesis. Additionally, he has worked with neglected tropical diseases like Dengue and is currently working to understand the parasitic disease Lymphatic Filariasis burden in Nepal. In addition to functional immunology during infection, he also has a special interest in B cell ontogeny and how it is affected by germinal centre remodulation during infection and immunization. Apart from infection, he is also equally interested in non-communicable disease immune pathology including diabetes and autoimmune disorders.
