Jae Kyung Sohng

Jae Kyung Sohng received his M.S. (Organic Chemistry, 1986) from Yonsei University, Korea and Ph.D (Biochemistry, 1991) from Brown University, USA under the supervision of Prof. David E. Cane. Till 1994, he worked as post-doctoral fellow at University of Washington in Prof. Heinz G. Floss’s lab. Currently, he is a Professor at Department of BT Convergent Pharmaceutical Engineering at Sun Moon University and a Director of Institute of Biomolecule Reconstruction. He studied the biosynthesis pathways of sugar containing natural products. Recently, he is focusing on the biosynthesis of novel natural product glycosides by metabolic engineering of microbes.

Till date, he has already supervised more than 40 PhD students and similar number of MSc students.

Education

• B.S., Yonsei University, Dept of Chemistry, 1984
• M.S., Yonsei University, Dept of Chemistry, 1986
• Ph.D, Brown University Dept. of Chemistry, 1991

Career

• March 2010 – Feb. 2012, College of Health Science (Dean)
• March 2010 – June 2011, Integrative Graduate School in Medicine, Sun Moon University (Director)
• March 2002 – present, Institute of Biomolecule Reconstruction (Director)
• March 2003 – present, Dept. of Pharmaceutical Engineering, Sun Moon University (Professor)
• March 1998 – Feb 2003, Dept. of Chemistry, Sun Moon University (Associate Professor)
• March 1994 – Feb 1998, Dept. of Chemistry, Sun Moon University (Assistant Professor)
• July 1991 – Feb 1994, University of Washington, (Post-doc)
• January 2010 – present, Asian Communications of Glycobiology and Glycotechnology (Steering Committee)
• January 2012 – present, Korean Society of Glycosicence (Vice president)
• January 2010 – Dec 2011, Korean Society of Glycosicence (Chief-Secretary)
• January 2006 – Dec 2009, Academy, Korean Society of Glycosicence (Secretary)
• January 2006 – Dec 2007, Biological Engineering Committee, Korea Society for Industrial and Engineering Chemistry (President)
• January 2007 – Dec 2008, Academy Committee, Korea Society for Pharmaceutical Engineering (Secretary)
• January 2002 – Dec 2003, Life Science Committee, Korea Society for Chemistry (Secretary)
• January 2000 – Dec 2001, Biochemistry News, Korea Society for Biochemistry (Secretary)

Awards

2010, Ujae Award, Korea Society for Microbiology and Biotechnology

2010, Outstanding Paper Award, Korean Federation of Science and Technology

Publications

1. Williard PG, Sohng JK, Cane DE. “The X-ray crystal structure of pentalenolactone F methyl ester (epi-pentalenolactone F)” Antibiot (Tokyo). 1988 Jan;41(1):130-3.
2. Cane DE, Sohng JK. “Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone: kinetic and mechanistic studies” Arch Biochem Biophys. 1989, 270, 50-61.
3. Cane DE, Sohng JK, Lamberson CR, Rudnicki SM, Wu Z, Lloyd MD, Oliver JS, Hubbard BR. “Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319” Biochemistry. 1994, 33, 5846-57.
4. Cane DE, Sohng JK. “Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone. 2. Identification of the site of alkylation by tetrahydropentalenolactone.” Biochemistry. 1994 Ma, 33, 6524-30.
5. Bechthold A, Sohng JK, Smith TM, Chu X, Floss HG. “Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin” Mol Gen Genet. 1995, 248, 610-20.
6. Sohng JK., Yoo JC. “Cloning, Sequencing and a Expression of dTDP-D-glucose 4,6-dehydratase gene from Streptomyces antibioticus Tu99, a Producer of Chlorothricin” J. Biochem. Mol. Biol. 1996, 29, 183-191
7. Sohng JK., Oh TJ., Kim CK., Lee JJ. “Cloning and Analysis of Rubradirin Biosynthetic Genes from S. achromogenes var. rubradiris NRRL 306” Mol. Cells 1997, 7, 674-681.
8. Sohng JK, Noh HR and Yoo JC, Mechanism study of dTDP-D-glucose 4,6-dehydratase: general base in active site domain. J. Biochem. Mol. Biol. 1999, 32, 358-362.
9. Sohng JK, Lee EH, Han JM, Bang HJ, and Yoo JC, “Expression of orf8 (chlD) as glucose-1-phosphate thymidylytransferase involved in olivose biosynthesis from Streptomyces antibioticus Tü99 and biochemical properties of the expressed protein” J. Biochem. Mol. Biol. 1999, 32, 363-369.
10. Yoo JC, Han JM, Sohng JK. “Expression of orf7 as dTDP-glucose 4,6-dehydratase gene cloned from Streptomyces antibioticus Tü99 and biochemical characteristics of recombinant protein. J. Microbiol. Biotechnol. 1999, 9 206-212.
11. Hyun CC., Kim SS., Sohng JK, Hahn JJ, Kim JW, Suh JW. “An efficient approch for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer” FEMS Microbiol. Lett., 2000, 138, 183-189.
12. Yoo JC., Choi JY., Yun SC., Kim CG., Lee JJ., Kim SB, Sohng JK. “Sequence Analysis and Expression of rubN2 as dTDP-Glucose 4,6-Dehydratase Gene Cloned from Streptomyces achromogenes var. rubradiris NRRL3061, Rubradirin Producer” J. Biochem. Mol. Biol. Biophys., 2000, 4, 313-321.
13. Sohng JK, Oh TJ, Cha JH, Hanh JJ, Kim JW, Suh JW, Lee HC, “Cloning and indentification of a gene cluster in Streptomyces spectabilis-Spectinomycin producer” J. Biochem. Mol. Bio. Biophys., 2001, 5, 209-218.
14. Choi CH, Sun KH, An CS, Yoo JC, Hahm KS, Lee IH, Sohng JK, Kim YC. “Reversal of P-lycoprotein-mediated multidrug resistance by 5,6,7,3′,4′-pentamethoxyflavone (Sinensetin)” Biochem.l Biophy. Res. Comm. 2002, 295, 832-540.
15. Sohng JK, Noh HR, Lee OH, Kim SJ, Han JM, Nam SK, Yoo JC.. “Function of Lysine-148 in dTDP-D-Glucose 4,6-Dehydratase from Streptomyces antibioticus Tu99” J. Microbiol. Biotechnol. 2002, 12, 217-221.
16. Maharjan J, Liou K, Lee HC, Kim CG, Lee JJ, Yoo JC, Sohng JK. “Identification of rub52 gene involve in thebiosynthesis of rubradirin” Biotech. Lett. 2003, 25, 909-915.
17. Sohng JK, Lee HC, Liou K, Lee EB, Kang SY, Woo JS. “Cystocin, a Novel Antibiotic, Produced by Streptomyces spGCA0001: Production and characterization of Cystocin” J. Microbiol, Biotechnol. 2003, 13, 483-486.
18. Oh J, Lee SG, BKim BG, JSohng JK, Liou K, HC. “One-Pot Enzymatic Production of TDP-4-keto-6-deoxy-D-glucose from dTMP and Glucose-1-phosphate“ Biotech. Bioeng. 2003, 84, 452-458
19. Kharel MK, Subba B, Lee HC, Liou K, Woo JS, Kim DH, Moon YH, Sohng JK.. “Identification of 2-Deoxy-scyllo-inosose Synthase in Aminoglycoside Producer Streptomyces” J. Microbiol. Biotechnol. 2003, 13, 828-831
20. Kharel MK, Subba B, Lee HC, Liou K, Wo JS, Shong. JK. “An Approach For Cloning Biosynthetic gene of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius” Biotech. Lett. 2003, 2, 2041-2047.
21. Lee HC, Liou K, Kim DH, Kang SY, Woo JS, Sohng JK. “Cystocin, a Novel Antibiotic, Produced by Streptomyces spGCA0001: Biological Activities” Arch. Pharm. Res. 2003, 26, 446-448.
22. Kharel MK, Basnet DB, Lee HC, Liou K, Woo JS, Kim BG, Sohng JK. “Isolation and Characterization of the tobramycin biosynthetic gene cluster from Streptomyces tenebrarius” FEMS Microbiol. Lett. 2004, 230, 185-190.
23. Jo YY, Kim SH, Yang YY, Kang CM, Sohng JK, Suh JW. “Functional Analyasis of Spectinomycin Biosynthetic Genes From Streptomyces Spectabilis ATCC 27741” J. Microbiol. Biotechnol. 2003, 13, 906-911.
24. Parajuli N, Lee DS, Lee HC, Liou K, Sohng JK. “Cloning, expression and characterization of glucose-1-phosphate thymidylyltransferase (strmlA) from Thermus caldophilus” Biotech. Lett. 2004, 26, 437-442.
25. Parajuli N, Basnet DB, Lee HC, Sohng JK, Liou K. “Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces” Arch. Biochem. Biophy. 2004, 425, 233-241.
26. Lee HC, Sohng JK, Kim HJ, Nam DH, Han JM, Cho SS, Choi JH, Yoo JC. “Cloning and Expression of the Glucose-1-Phosphate Thymidylyltransferase Gene (gerD) from Streptomyces sp. GERI-155” Mol. Cells, 2004, 17, 274-280.
27. Kharel MK, Liou K, Sohng JK, Lee HC. “Production of dTDP-4-keto-6-deoxy-D-glucose by Immobilization of dTDP-D-glucose 4,6-dehydratase” J. Microbiol. Biotechnol. 2004, 14, 297-301.
28. Sthapit B, Oh TJ, Lamichhane R, Liou K, Lee HC, Kim CG, Sohng JK. “Neocarzinostatin naphthoate synthase: an unique iterative type IPKS from neocarzinostatin producer Streptomyces carzinostaticus” FEBS Lett. 2004, 566, 201-206.
29. Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK.. “A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster” Arch. Biochem. Biophy. 2004, 429, 204-214.
30. Kharel MK, Basnet DB, Lee HC, Liou K, Moon YH, Kim JJ, Woo JS, Sohng JK. “Cloning and Characterization of a 2-Deoxystreptamine Biosynthetic Gene Cluster in Gentamicin-producing Micromonospora echinospora ATCC15835” Mol. Cells 2004, 18,. 71-78.
31. Hong JSJ, Park SH, Choi CY, Sohng JK, Yoon YJ. “New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae” FEMS Microbiol. Lett. 2004, 238, 391-399.
32. Lee SK, Basnet DB, Choi CY, Sohng JK, Ahn JS, Yoon YJ. “The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis” Bioorg. Chem. 2004, 32, 549-559.
33. Hong YS, Lee DH, Kim WC, Jeong JK, Kim CG, Sohng JK, Lee JH, Paik SG, Lee JJ. “Inactivation of the Carbamoyltransferase Gene Refines Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Geldanamycin” J. Am. Chem. Soc. 2004, 126, 11143-11144
34. Lee HC, Lee SD, Sohng JK, Liou K. One-pot Enzymatic “Synthesis of UDP-D-glucose from UMP and Glucose-1-phosphate Using an ATP Regeneration System” J. Biochem. Mol. Biol., 2004, 37, 503-506.
35. Sohng JK, Kim HJ, Nam DH, Lim DO, Han JM, Lee HJ, Yoo JC. “Cloning, expression, and biological function of a dTDP-deoxyglucose epimerase (gerF) gene from Streptomyces sp. GERI-155” Biotechnol. Lett. 2004, 26, 185-191.
36. Kharel MK, Subba B, Lee HC, Liou K, Sohng JK. “Characterization of L-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius” Bioorgan. Med. Chem. Lett., 2005, 15, 89-92.
37. N Parajuli, DB Basnet, YS Chung, HC Lee, K Lio, JK Sohng “Biochemical Characterization of a Novel Thermostable Glucose-1-phosphate thymidylyltransferase from Thermuscaldophilus: Probing the Molecular Basis for Its Unusual Thermostability” Enzy. Microbiol. Technol. 2005, 37, 402-409
38. TTT Thuy, HC Lee, CG Kim L Heide, JK Sohng “Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides” Arch. Biochem. Biophy. 2005, 436 161-167
39. N Parajuli, HT Viet, K Ishida, HT Tong, HC Lee, K Liou, JK Sohng “Identification and characterization of afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952” Res. Microbiol. 2005, 156, 707-712
40. ML Thuy, MK Kharel, R Lamichhane, HC Lee, JWo Suh, K Liou, JK Sohng “Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans” Biotechnol. Lett. 2005, 27, 465-470
41. B Subba, MK Kharel, H Lee, K Liou, BG Kim, JK Sohng “The Ribostamycin Biosynthetic Gene Cluster in Streptomyces ribosidificus: Comparison with Butirosin Biosynthesis” Mol. Cells 2005, 20, 90-96
42. SK Lee, DB Basnet, JSJ Hong, WS Jung, CY Choi, HC Lee, JK Sohng, KG Ryu, DJ Kim, JS Ahn, BS Kim, HC Oh, DH Sherman, YJ Yoon. “Strutural diversification of macrolactones by Substrate-flexible cytochrome P450 monooxygenase” Adv. Synth. Catal. 2005, 347, 1369-1378
43. YH Yang, HS Joo, K Lee, K Liou, HC Lee, JK Sohng, BG Kim “Novel Method for detection of butanolides in Streptomyces coelicolor culture broth, using a his-tagged receptor (ScbR) and Mass spectrometry” Appl. Environ. Microbiol. 2005, 71, 5050-5055.
44. Y Kang, Y Yang, K Lee, SG Lee, JK Sohng, HC Lee, K Liou, BG Kim “Preparative synthesis of dTDP-L-rhamnose through combined enzymatic pathways” Biotech. Bioeng. 2006, 93, 21-27
45. WS Jung, SK Lee, JSJ Hong, SR Park, SJ Jeong, CY Choi, DH Shernman, YJ Yoon. “Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae” Appl. Microbioal. Biotechnol., 2006, 72, 763-769
46. K Ishida, TV Hung, K Liou, HC Lee, C Shin, YJ Yoon, JK Sohng, “Degradation of clavulanic acid during the cultivation of Streptomyces clavugerus; Instability of clavulanic acid by metabolites and proteins from the strains. J. Microbiol. Biotechnol. 2006, 16, 590-596.
47. J Lamichhane, K Liou, HC Lee, CG Kim, JK Sohng. “Functional characterization of ketoreductase (rubn6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris. Biotech. Lett., 2006, 29, 545-553.
48. BP Jaishy, SK Lim, ID Yoo, JC Yoo, JK Sohng, DH Nam. “Clong and characterization of a gene cluster for the production of polyketide macrolide dihydrochalcomycin in Streptomyces sp. KCTC 0041BP” J. Microbiol. Biotechnol. 2006, 16, 764-770.
49. J. Lamichhane, TJ Oh, K Liou, HC Lee, CG Kim, JK Sohng. “mediation of rubradirin resistance by ABC transporters (RubT1) from Streptomyces achromogenes var. rubradiris NRRL3061. J. Microbiol. Biotechnol. 2006, 16, 1928-1934.
50. D Basnet, TJ Oh, TTH Vu, B Sthapit, JC Yoo, K Liou, HC Lee, JK Sohng. “Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization” Mol. Cells 2006, 22, 154-162.
51. Trinh Viet Hung, Kenji Ishida, Niranjan Parajuli, Kwangkyoung Liou, Hei Chan Lee and Jae Kyung Sohng, “Enhanced clavulanic acid production in Streptomyces clavuligerus NRRL3585 by overexpression of regulatory genes” Biotech. Biopro. Enginee. 2006, 11, 116-120
52. KW Lee, E Song, J Kim, HC Lee, K Liou, HC Lee, JK Sohng, -G Kim “Enhanced proteomic analysis of Streptomyces peucetius ctosolic protein using optimized protein solubilization protocol”. J. Microbiol. Biotechnol. 2007, 17, 89-45
53. B Subba, NP Kurumbang, YS Jung, YJ Joon, HC Lee, K Liou, JK Sohng “Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividanse TK24” Bioorg. Med. Chem. 2007, 17, 1892-1896.
54. TTT Thuy, K Liou, TJ Oh, DH Kim, DH Nam, JC Yoo, JK Sohng “Biosynthesis of dTDP-6-deoxy-D-allose, Biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerK1) from Streptomyces sp. KCTC 0041BP” Glycobiology 2007, 17, 119-126
55. Chung YS, Kim DH, Seo WM, Lee HC, Liou K, Oh TJ, Sohng JK. “Enzymatic synthesis of dTDP-4-amino-4,6-dideoxy-d-glucose using GerB (dTDP-4-keto-6-deoxy-d-glucose aminotransferase)” Carbohydr Res. 2007, 1412-1418.
56. Kim JH, Yun J, Sohng JK, Cha JM, Choi BC, Jeon HJ and Choi CH “Di (2-ethylhexyl)phthalate leached from medical PVC devices serves as a substrate and inhibitor for the P-glycoprotein” Enviro. Toxicol. Pharm. 2007, 23, 272-278
57. Thapa LP, Oh TJ, Lee HC, Liou K, Park JW, Yoon YJ, Sohng JK. “Heterologous expression of the kanamycin biosynthetic gene cluster (pSKC2) in Streptomyces venezuelae YJ003” Appl. Microbiol. Biotechnol. 2007, 76, 1357-64.
58. Hung TV, Malla S, Park BC, Liou K, Lee CH, Sohng JK “Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. J. Microbiol. Biotechnol. 2007, 17, 1538-1545
59. Pageni BB, Oh TJ, Liou K, Yoon YJ, Sohng JK, “Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelae YJ003-OTBP3” J. Microbiol. Biotechnol. 2008, 18, 88-94
60. Oh TJ, Mo SJ, Yoon YJ, Sohng JK. “Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes” J. Microbiol. Biotechnol. 2007, 17, 1902-1921
61. Jin Cheol Yoo, Jun Ho Kim, Jung Wan Ha, Nae Soo Park, Jae Kyung Sohng, June Woo Lee, Keun Sik Baik, Mi Sun Kim, and Chi Nam Seong “Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684” Journal of Microbiology (2007) 45, 6-10.
62. Kim CG, Lamichhane J, Song KI, Nguyen VD, Kim DH, Jeong TS, Kang SH, Kim KW, Maharjan J, Hong YS, Kang JS, Yoo JC, Lee JJ, Oh TJ, Liou K, Sohng JK “Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061” Arch. Microbiol. 2008, 189, 463-473
63. Shrestha P, Oh TJ, Sohng JK. “Designing a whole-cell biotransformation system in Escherichia coli using cytochrome P450 from Streptomyces peucetius” Biotech. Lett. 2008, 30, 1101-1106
64. Thapa LP, Oh TJ, Liou K, Sohng JK. “Biosynthesis of spectinomycin: heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host, Streptomyces venezuelae YJ003” J. Appl. Microbiol. 2008, 105, 300-308
65. Maharjan S, Oh TJ, Lee HC, Sohng JK. “Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin.” Biotech. Lett. 2008, 30, 1621-1626
66. Pageni BB, Oh TJ, Lee HC, Sohng JK. “Metabolic engineering of noviose: heterologous expression of novWUS and generation of a new hybrid antibiotic, noviosylated 10-deoxymethynolide/narbonolide, from Streptomyces venezuelae YJ003-OTBP1.” Biotech. Lett. 2008, 30, 1609-1615
67. Pageni BB, Oh TJ, Sohng JK. “Functional characterization of orf6 and orf9 genes involved in the biosynthesis of L-oleandrose from Streptomyces antibioticus Tü 99” Biotech. Bioprocess Eng. 2008, 13, 752-757
68. Shrestha P, Oh TJ, Liou K, Sohng JK. “Cytochrome P450 (CYP105F2) from Streptomyces peucetius and its activity with oleandomycin.” Appl Microbiol Biotechnol. 2008 79, 555-562.
69. Park JW, Hong JS, Parajuli N, Jung WS, Park SR, Lim SK, Sohng JK, Yoon YJ. “Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set” Proc. Natl. Acad. Sci. USA. 2008 105, 8399-8404.
70. Pageni BB, Oh TJ, Thuy TT, Sohng JK. “Characterization of a Chalcosyltransferase (gerGTII) in Dihydrochalcomycin Biosynthesis” Mol Cells. 2008, 26. 278-284
71. Ghimire GP, Oh TJ, Liou K, Sohng JK. “Identification of a Cryptic Type III Polyketide Synthase (1,3,6,8-Tetrahydroxynaphthalene Synthase) from Streptomyces peucetius ATCC 27952” Mol. Cells. 2008, 26, 362-367
72. Kurumbang NP, Oh TJ, Liou K, Sohng JK. “Heterologous production and detection of recombinant directing 2-deoxystreptamine (DOS) in the non-aminoglycoside-producing host Streptomyces venezuelae YJ003” J. Microbiol. Biotechnol. 2008, 18, 866-873.
73. Ghimire GP, Oh TJ, Lee HC, Kim BG, Sohng JK. “Cloning and Functional Characterization of the Germacradienol Synthase (spterp13) from Streptomyces peucetius ATCC 27952” J Microbiol Biotechnol. 2008, 18, 1216-1220.
74. Park SR, Park JW, Jung WS, Han AR, Ban YH, Kim EJ, Sohng JK, Sim SJ, Yoon YJ. “Heterologous production of epothilones B and D in Streptomyces venezuelae” Appl Microbiol Biotechnol 2008, 81, 109-117
75. Simkhada D, Oh TJ, Kim EM, Yoo JC, Sohng JK. “Cloning and characterization of CalS7 from Micromonospora echinospora sp. calichensis as a glucose-1-phosphate nucleotidyltransferase” Biotechnol Lett. 2008, 147-153
76. Nepal K, Oh TJ, Subba B, Yoo JC, Sohng JK. “Characterization of RbmD (Glycosyltransferase in Ribostamycin Gene Cluster) through Neomycin Production Reconstituted from the Engineered Streptomyces fradiae BS1.” Mol Cells. 2009, 27, 83-88.
77. Simkhada JR, Lee HJ, Jang SY, Kim JH, Lee HC, Sohng JK, Yoo JC. “A novel low molecular weight phospholipase D from Streptomyces sp. CS684.” Bioresour Technol. 2009, 100, 1388-1393.
78. Sohng JK, Yamaguchi T, Seong CN, Baik KS, Park SC, Lee HJ, Jang SY, Simkhada JR, Yoo JC. Production, isolation and biological activity of nargenicin from Nocardia sp. CS682. Arch. Pharm. Res. 2008, 31, 1339-1345.
79. Park SH, Park HY, Sohng JK, Lee HC, Liou K, Yoon YJ, Kim BG. Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening. Biotechnol. Bioeng. 2009, 102, 988-994
80. Jnawali HN, Oh TJ, Liou K, Park BC, Sohng JK. A Two-component Regulatory System Involved in Clavulanic Acid Production. J. Antibiot. 2008, 61, 651-659.
81. Yang JR, Song E, Kim BG, Kim ES, Sohng JK, Oh MK. Expression profiling of Streptomyces peucetius metabolic genes using DNA microarray analysis Biotech. Bioprocess Eng. 2008 13, 738-744.
82. Simkhada JR, Lee HJ, Jang SY, Cho SS, Park EJ, Sohng JK, Yoo JC. A novel alkalo- and thermostable phospholipase D from Streptomyces olivochromogenes. Biotechnol. Lett. 2009, 31, 429-435
83. Ghimire GP, Oh TJ, Lee HC, Sohng JK.. Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: sequence analysis, expression and functional characterization. Biotechnol. Lett. 2009 31, 565-9.
84. Tae HS, Sohng JK, Park KJ. “Development of an analysis program of type I polyketide synthase gene clusters using homology search and profile hidden Markov model” J. Microbiol. Biotechnol. 2009 19, 140-6.
85. Sushila M, Oh TJ, Lee CH, Sohng JK., Identification and Functional Characterization of an afsR Homolog. J Microbiol Biotechnol 2009 19, 121-7.
86. Tae H, Sohng JK, Park K. “MapsiDB: an integrated web database for type I polyketide synthases.” Bioprocess Biosyst Eng. 2009 32, 723-7
87. Jnawali HN, Subba B, Liou K, Sohng JK. “Functional characterization of kanB by complementing in engineered Streptomyces fradiae neo6::tsr” Biotechnol. Lett. 2009 31, 869-75.
88. Nepal KK, Oh TJ, Subba B, Yoo JC, Sohng JK. “Characterization of RbmD (glycosyltransferase in ribostamycin gene cluster) through neomycin production reconstituted from the engineered Streptomyces fradiae BS1. Mol. Cells. 2009 27, 83-8.
89. Cho SS, Sohng JK, Lee HJ, Park SJ, Simkhada JR, Yoo JC “Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by high performance liquid chromatography.” Arch. Pharm. Res. 2009, 32, 335-40.
90. Nepal KK, Oh TJ, Sohng JK. “Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853.” Mol. Cells. 2009, 27, 601-8.
91. Park SS, Yang YH, Song E, Kim EJ, Kim WS, Sohng JK, Lee HC, Liou KK, Kim BG. “Mass spectrometric screening of transcriptional regulators involved in antibiotic biosynthesis in Streptomyces coelicolor A3(2).” J Ind Microbiol Biotechnol. 2009 36, 1073-83.
92. Singh B, Oh TJ, Sohng JK. “Exploration of geosmin synthase from Streptomyces peucetius ATCC 27952 by deletion of doxorubicin biosynthetic gene cluster.” J Ind Microbiol Biotechnol. 2009 36, 1257-65.
93. Pageni BB, Oh TJ, Sohng JK. “Novel desosaminyl derivatives of dihydrochalcomycin from a genetically engineered strain of Streptomyces sp.” Biotechnol Lett. 2009, 31, 1759-1768
94. Malla S, Niraula NP, Liou K, Sohng JK. “Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius.”J Biosci Bioeng. 2009, 108, 92-8.
95. Malla S, Niraula NP, Liou K, Sohng JK. “Self-resistance mechanism in Streptomyces peucetius: Overexpression of drrA, drrB and drrC for doxorubicin enhancement.” Microbiol. Res. 2010, 165, 259-267.
96. Ghimire GP, Lee HC, Sohng JK. “Improved squalene production via modulation of the methyl-erythritol 4-phosphate pathway and heterologous expression of genes from Streptomyces peucetius ATCC 27952 in Escherichia coli.” Appl Environ Microbiol. 2009 75, 7291-7193
97. Shrestha P, Oh TJ, Niraula NP, Liou K, Yoo JC, Sohng JK “Characterization of CYP166B1 and its electron transfer system in Streptomyces peucetius var. caesius ATCC 27952” Enzy. Microbial. Technol. 2010, 46, 372-377.
98. Singh B, Lee CB, Sohng JK. “Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952.” Appl. Microbiol Biotechnol. 2010, 85, 1565-74.
99. Simkhada D, Kim E, Lee HC, Sohng JK. “Metabolic engineering of Escherichia coli for the biological synthesis of 7-O-xylosyl naringenin.” Mol Cells. 2009, 28, 397-401.
100. Mander P, Simkhada JR, Cho SS, Park SJ, Choi HS, Lee HC, Sohng JK, Yoo JC. “A novel Ca2+-dependent phospholipase D from Streptomyces tendae, possessing only hydrolytic activity.” Arch Pharm Res. 2009, 32, 1461-7.
101. Park SH, Park HY, Cho BK, Yang YH, Sohng JK, Lee HC, Liou K, Kim BG. “Reconstitution of antibiotics glycosylation by domain exchanged chimeric glycosytransferase” J. Mol. Cat. B.: Enz 2009, 60, 29-35.
102. Maharjan S, Park JW, Yoon YJ, Lee HC, Sohng JK. “Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides.” Biotechnol. Lett. 2010, 32, 277-282.
103. Malla S, Niraula NP, Liou K, Sohng JK. “Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius” Res. Microbiol. 2010, 161, 109-117.
104. Pageni BB, Simkhada D, Oh TJ, Sohng JK. “Biosynthesis of dihydrochalcomycin: Characterization of a deoxyallosyltransferase (gerGTI)” Mol. Cells. 2010, 29, 153-158.
105. Jnawali HN, Lee HC, Sohng JK. “Enhancement of Clavulanic Acid Production by Expressing Regulatory Genes in gap Gene Deletion Mutant of Streptomyces clavuligerus NRRL3585” J. Microbiol. Biotechnol. 2010, 20, 146-152.
106. Oh TJ, Niraula NP, Liou K, Sohng JK. “Identification of the duplicated genes for S-adenosyl-l-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952” J. Appl. Microbiol. 2010, 109, 398-407.
107. Malla S, Niraula NP, Sinh B, Liou K and Sohng JK “Limitations in doxorubicin production from Streptomyces peucetius. Microbiol. Res. 2010, 165, 427-435
108. Kaysser L, Wemakor E, Siebenberg S, Salas JA, Sohng JK, Kammerer B, Gust B.“ Carprazamycin biosynthesis: formation and attachment of the deoxysugar moiety and assemble of the gene cluster” Appl. Environ. Microbiol. 2010, 76, 4008-4018
109. Niraula NP, Shrestha P, Oh TJ, Sohng JK. “Identification and characterization of a NADH oxidoreductase involved in phenylacetic acid degradation pathway from Streptomyces peucetius.” Microbiol. Res. 2010, 165, 649-56.
110. Simkhada D, Lee HC, Sohng JK. “Genetic engineering approach for the production of rhamnosyl and allosyl flavonoids from Escherichia coli.” Biotechnol. Bioeng. 2010, 107, 154-162.
111. Niraula NP, Kim SH, Sohng JK, Kim ES. “Biotechnological doxorubicin production: pathway and regulation engineering of strains for enhanced production.” Appl. Microbiol. Biotechnol. 2010, 87, 1187-1194.
112. Kurumbang NP, Park JW, Yoon YJ, Liou K, Sohng JK. “Heterologous production of ribostamycin derivatives in engineered Escherichia coli.” Res. Microbiol. 2010, 161, 526-533.
113. Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG. “Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9” Biochem. Biophys. Res. Commun. 2010, 399, 133-138.
114. Kurumbang NP, Liou K, Sohng JK. “Biosynthesis of paromamine derivatives in engineered Escherichia coli by heterologous expression.” J. Appl. Microbiol. 2010, 108, 1780-1788
115. Hang VT, Oh TJ, Yamaguchi T, Sohng JK. “In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore” FEMS Microbiol. Lett. 2010, 311, 119-125.
116. Jnawali HN, Liou K, Sohng JK. “Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585” Microbiol Res. 2011, 166, 369-79
117. Kanth BK, Jnawali HN, Niraula NP, Sohng JK “Superoxide dismutase (SOD) genes in Streptomyces peucetius: Effects of SODs on secondary metabolites production” Microbiol Res. 2011, 166, 391-402
118. Kanth BK, Liou K, Sohng JK. “Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952” Comput Biol Chem. 2010, 34, 226-31.
119. Malla S, Thuy TT, Oh TJ, Sohng JK. “Identification and characterization of gerPI and gerPII involved in epoxidation and hydroxylation of dihydrochalcolactone in Streptomyces species KCTC 0041BP” Arch Microbiol. 2011, 193, 95-103
120. Oh TJ, Kim DH, Kang SY, Yamaguchi T, Sohng JK. “Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase” J Antibiot 2011, 64, 103-109.
121. Simhada D, Kurumbang NP, Lee HC, Sohng JK. “Exploration of glycosylated flavonoids from metabolically engineered E. coli” Biotech. Bioprocess Eng. 2010 15 754-760.
122. Nepal KK, Yoo JC and Sohng JK “Functional characterization of KanP, a methyltransferase from the kanamycin biosynthetic gene cluster of Streptomyces kanamyceticus” Microbiological Research 2010, 165, 557-564.
123. Kanth BK, Oh TJ, Sohng JK “Identification of two superoxide dismutase (FeSOD and NiSOD) from Streptomyces peucetius ATCC 27952” Biotech. Bioprocess Eng. 2010, 15, 785-792.
124. Simkhasa JR, Cho SS, Choi HS, Kim SW, Lee HC, Sohng JK, Yoo JC “A New.Themolabile Alkaline Phospholipase D from Streptomyces sp. CS628” Biotech. Bioprocess Eng. 2010, 15, 595-602.
125. Mandakh A, Niraula NP, Kim EP, Sohng JK. “Identification and characterization of a pantothenate kinase (PanK-sp) from streptomyces peucetius ATCC 27952” J Microbiol Biotechnol. 2010, 20, 1689-95.
126. Nepal KK, Yoo JC, Sohng JK. “Biosynthetic approach for the production of new aminoglycoside derivative” J Biosci Bioeng. 2010 110, 109-12.
127. Song E, Malla S, Yang YH, Lee K, Kim EJ, Lee HC, Sohng JK, Oh MK, Kim BG. “Proteomic approach to enhance doxorubicin production in panK-integrated Streptomyces peucetius ATCC 27952“ J Ind Microbiol Biotechnol. 2011, 38, 1245-1253.
128. Jnawali HN, Yoo JC, Sohng JK. “Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes.” Biotechnol Lett. 2011, 33, 1221-1226.
129. Park JW, Park SR, Han AR, Ban YH, Yoo YJ, Kim E, Kim BS, Sohng JK, Yoon YJ. “Characterization and identification of pradimicin analogs from Actinomadura hibisca using liquid chromatography-tandem mass spectrometry.” J Chromatogr A. 2011, 1218, 2284-2291.
130. Boll B, Hennig S, Xie C, Sohng JK, Heide L. “Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains.” Chembiochem. 2011, 12, 1105-14.
131. Paudel S, Lee HC, Kim BS, Sohng JK. “Enhancement of pradimicin production in Actinomadura hibisca P157-2 by metabolic engineering” Microbiol Res. 2011, 167, 32-39.
132. Han AR, Park JW, Lee MK, Ban YH, Yoo YJ, Kim EJ, Kim E, Kim BG, Sohng JK, Yoon YJ. “Development of Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates” Appl Environ Microbiol. 2011, 77, 4912-4923.
133. Kurumbang NP, Liou K, Sohng JK. “Biosynthesis of Ribostamycin Derivatives by Reconstitution and Heterologous Expression of Required Gene Sets” Appl. Biochem. Biotechnol. 2011, 163, 373-382.
134. Yang YH, Kang YB, Kim DH, Lee TH, Park SH, Lee K, Yoo D, Liou K, Lee HC, Sohng JK, Kim BG. “One-pot enzymatic synthesis of deoxy-thymidine-diphosphate(TDP)-2- deoxy-a-D-glucose using phosphomannomutase” J of Molecular Catalysis B: Enzymatic. 2010, 62, 282-287.
135. Hang VTT, Kim TS, Oh TJ, Sohng JK. “Influence of apoproteins for enediyne production” Biotech. Biopro. Eng. 2011, 16, 462-469.
136. Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EM, Kim D, Sohng JK, Yoon YJ. “Discovery of parallel pathways in kanamycin biosynthesis allows antibiotic manipulation” Nat. Chem. Biol. 2011, 7, 843-852.
137. Niraula NP, Kanth BK, Sohng JK, Oh TJ. “Hydrogen peroxide-mediated dealkylation of 7-ethoxycoumarin by cytochrome P450 (CYP107AJ1) from Streptomyces peucetius ATCC27952” Enzyme Microb Technol. 2011, 48, 181-186.
138. Paudel S, Park JW, Lee JH, Yoon YJ, Sohng JK. “Functional Analysis of ABC Transporter Genes pdmR1 and pdmR2 in Actinomadura hibisca P-1752 and Enhancement of Pradimicin Production” Biotech. Bioprocess Eng. 2012, 17, 8-15.
139. Maharjan S, Koju D, Lee HC, Yoo JC, Sohng JK. “Metabolic engineering of Nocardia sp. CS682 for enhanced production of nargenicin A” Appl Biochem Biotechnol. 2012 Feb;166(3):805-17.
140. Singh B, Lee CB, Park JW, Sohng JK. “The amino acid sequences in the C-terminal region of glucose-1-phosphate thymidylyltransferases determine their soluble expression in Escherichia coli.” Protein Eng Des Sel. 2012 Apr;25(4):179-87.
141. Maharjan S, Aryal N, Bhattarai S, Koju D, Lamichhane J, Sohng JK. “Biosynthesis of the nargenicin A1 pyrrole moiety from Nocardia sp. CS682.” Appl Microbiol Biotechnol. 2012 Jan;93(2):687-96.
142. Cho SS, Park DA J, Simkhada JR, Hong JH, Sohng JK, Lee OH, Yoo JC. “A neutral lipase applicable in biodiesel production from a newly isolated Streptomyces sp. CS326” Bioprocess Biosyst Eng. 2012 Jan;35(1-2):227-34.
143. Niraula NP, Bhattarai S, Lee NR, Sohng JK, Oh TJ. “Biotransformation of flavone by CYP105P2 from Streptomyces peucetius.” J Microbiol Biotechnol. 2012 Aug;22(8):1059-65.
144. Koju D, Maharjan S, Dhakal D, Yoo JC, Sohng JK. “Effect of different biosynthetic precursors on the production of nargenicin A1 from metabolically engineered Nocardia sp. CS682.” J Microbiol Biotechnol. 2012 Aug;22(8):1127-32.
145. Park HM, Kim BG, Chang D, Malla S, Joo HS, Kim EJ, Park SJ, Sohng JK, Kim PI. “Genome-based cryptic gene discovery and functional identification of NRPS siderophore peptide in Streptomyces peucetius.” Appl Microbiol Biotechnol. 2013 Feb;97(3):1213-22.
146. Noh HJ, Im AR, Kim HS, Sohng JK, Kim CK, Kim YS, Cho S, Park Y. “Antibacterial activity and increased freeze-drying stability of sialyllactose-reduced silver nanoparticles using sucrose and trehalose.” J Nanosci Nanotechnol. 2012 May;12(5):3884-95.
147. Singh B, Oh TJ, Sohng JK. “Exploration of two epimerase homologs in Streptomyces peucetius ATCC 27952.” Appl Microbiol Biotechnol. 2013 Mar;97(6):2493-502.
148. Pandey RP, Malla S, Simkhada D, Kim BG, Sohng JK. “Production of 3-O-xylosyl quercetin in Escherichia coli.” Appl Microbiol Biotechnol. 2013 Mar;97(5):1889-901
149. Chaudhary AK, Park JW, Yoon YJ, Kim BG, Sohng JK, “Re-engineering of genetic circuit for 2-deoxystreptamine biosynthesis in Escherichia coli” Biotechnol. Lett. 2013 Feb;35(2):285-93.
150. Park SR, ParkJW, Ban YH, Sohng JK, Yoon YJ. 2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways. Nat.Prod.Rep.2013, 30(1):11-20.
151. Bhattarai S, Niraula NP, Sohng JK, Oh TJ. In-silico and In-vitro based studies of Streptomyces peucetius CYP107N3 for oleic acid epoxidation. BMB Rep. 2012 Dec;45(12):736-41.
152. Thuan NH, Yamaguchi T, Lee JH, Sohng JK. “Characterization of sterol glucosyltransferase from Salinispora tropica CNB-440: potential enzyme for the biosynthesis of sitosteryl glucoside” Enzyme Microb Technol. 2013 Apr 10;52(4-5):234-40.
153. Pandey RP, Li TF, Kim EH, Yamaguchi T, Park YI, Kim JS, Sohng JK. “Enzymatic synthesis of novel phloretin glucosides” Appl Environ Microbiol. 2013 Jun;79(11):3516-21.
154. Malla S, Pandey RP, Kim BG, Sohng JK. “Regiospecific modifications of naringenin for astragalin production in Escherichia coli” Biotechnol Bioeng. 2013 Sep;110(9):2525-35.
155. Ban YH, Shinde PB, Hwang JY, Song MC, Kim DH, Lim SK, Sohng JK, Yoon YJ. “Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration” J Nat Prod. 2013 Jun 28;76(6):1091-8.
156. Song MC, Kim E, Ban YH, Yoo YJ, Kim EJ, Park SR, Pandey RP, Sohng JK, Yoon YJ. “Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes” Appl Microbiol Biotechnol. 2013 Jul;97(13):5691-704.
157. Hoang NH, Huong NL, Shrestha A, Sohng JK, Yoon YJ, Park JW. “Regio-selectively reduced streptogramin A analogue, 5,6-dihydrovirginiamycin M1 exhibits improved potency against MRSA” Lett Appl Microbiol. 2013 Nov;57(5):393-8.
158. Chung MJ, Sohng JK, Choi DJ, Park YI. “Inhibitory effect of phloretin and biochanin A on IgE-mediated allergic responses in rat basophilic leukemia RBL-2H3 cells” Life Sci. 2013 Sep 17;93(9-11):401-8.
159. Pandey RP, Parajuli P, Koirala N, Park JW, Sohng JK. “Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC” Appl Environ Microbiol. 2013 Nov;79(21):6833-8.
160. Thuan NH, Sohng JK. “Recent biotechnological progress in enzymatic synthesis of glycosides” J Ind Microbiol Biotechnol. 2013 Nov;79(21):6833-8.
161. Kim HJ, Choi HS, Yang SY, Kim IS, Yamaguchi T, Sohng JK, Park SK, Kim JC, Lee CH, Gardener BM, Kim YC. “Both extracellular chitinase and a new cyclic lipopeptide, chromobactomycin, contribute to the biocontrol activity of Chromobacterium sp. C61” Mol Plant Pathol. 2014 Feb;15(2):122-32.
162. Lee JH, Pandey RP, Kim DH, Sohng JK “Cloning and functional characterization of an α-1,3-fucosyltransferase from Bacteroides fragilis” Biotechnology and Bioprocess Engineernig 2013, 18, 843-849.
163. Thuan NH, Pandey RP, Thuy TT, Park JW, Sohng JK “Improvement of regio-specific production of myricetin-3-O-α-L-rhamnoside in engineered Escherichia coli” Appl Biochem Biotechnol. 2013 Dec;171(8):1956-67.
164. Thuan NH, Park JW, Sohng JK “Toward the production of flavone-7-O-D-glucopyranosides using Arabidopsis glycosyltransferase in Escherichia coli” Process Biochemistry 2013 48: 1744-48.
165. Chaudhary AK, Dhakal D, Sohng JK. “An insight into the “-omics” based engineering of streptomycetes for secondary metabolite overproduction” Biomed Res Int. 2013;2013:968518.
166. Gurung RB, Kim EH, Oh TJ, Sohng JK. “Enzymatic synthesis of apigenin glucosides by glucosyltransferase (YjiC) from Bacillus licheniformis DSM 13” Mol Cells 2013 Oct;36(4):355-61.
167. Huong NL, Hoang NH, Shrestha A, Sohng JK, Yoon YJ, Park JW. “Biotransformation of rosamicin antibiotic into 10,11-dihydrorosamicin with enhanced in vitro antibacterial activity against MRSA” J Microbiol Biotechnol. 2014 Jan 28;24(1):44-7.
168. Jha AK, Lamichhane J, Sohng JK. “Enhancement of herboxidiene production in Streptomyces chromofuscus ATCC 49982” J Microbiol Biotechnol. 2014 Jan 28;24(1):52-8.
169. Lamichhane J, Jha AK, Singh B, Pandey RP, Sohng JK. “Heterologous production of spectinomycin in Streptomyces venezuelae by exploiting the dTDP-D-desosamine pathway” J Biotechnol. 2014 174, 57-63.
170. Choi O, Lee JK, Kang SY, Pandey RP, Sohng JK, Ahn JS, Hong YS. “Construction of artificial biosynthetic pathways for resveratrol glucoside derivatives.” J Microbiol Biotechnol. 2014 May;24(5):614-8.
171. Pandey RP, Kwon HJ, Ahn JS, Osada H, Sohng JK. “The 7th Japan-Korea chemical biology symposium: chemical biology of natural bioactive molecules.” ACS Chem Biol. 2014 May 16;9(5):1070-4.
172. Pandey RP, Parajuli P, Koirala N, Lee JH, Park YI, Sohng JK. “Glucosylation of isoflavonoids in engineered escherichia coli.” Mol Cells. 2014 Feb;37(2):172-7.
173. Koirala N, Pandey RP, Parajuli P, Jung HJ, Sohng JK. “Methylation and subsequent glycosylation of 7,8-dihydroxyflavone.” J Biotechnol. 2014 May 22;184C:128-137.
174. Pandey RP, Gurung RB, Parajuli P, Koirala N, Tuoi le T, Sohng JK “Assessing acceptor substrate promiscuity of YjiC-mediated glycosylation toward flavonoids.” Carbohydr Res. 2014 Jul 1;393:26-31.
175. Parajuli P, Pandey RP, Koirala N, Yoon YJ, Kim BG, Sohng JK. “Enzymatic synthesis of epothilone A glycosides.” AMB Express. 2014 Mar 20;4:31. doi: 10.1186
176. Le TT, Pandey RP, Gurung RB, Dhakal D, Sohng JK “Efficient enzymatic systems for synthesis of novel α-mangostin glycosides exhibiting antibacterial activity against Gram-positive bacteria.” Appl Microbiol Biotechnol. 2014 Oct;98(20):8527-38
177. Thuan NH, Pandey RP, and Sohng JK “Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives” Appl Microbiol Biotechnol. 2014 2014 Sep;98(18): 7747-59
178. Parajuli P, Pandey RP, Pokhrel AR, Ghimire GP, Sohng JK “Enzymatic glycosylation of the topical antibiotic mupirocin” Glycocojugate J 2014 Nov;31(8):563-72.
179. Chaudhary AK, Singh B, Maharjan S, Jha AK, Kim BG and Sohng JK “Switching antibiotics production on and off in Actinomycetes by an IclR family transcriptional regulator from Streptomyces peucetius ATCC 27952” J Microbiol Biotechnol. 2014 Aug 28;24(8):1065-72.
180. Lamichhane J. Chhetri SB, Bhandari M, Pohrel S, Pokharel A, Sohng JK “Ethpharmacological survey, phytochemical screening and antibacterial activity measurements of high atitute medicinal plants of Nepal: A bioprocessing approach. Indian Journal of Traditional Knowledge 13: 496-507.
181. Koirala N, Pandey RP, Van Thang D, Jung HJ, Sohng JK.” Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives.” J Ind Microbiol Biotechnol. 2014 Nov;41(11):1647-58.
182. Pandey RP, Parajuli P, Shin JY, Lee J, Lee S, Hong YS, Park YI, Kim JS, Sohng JK “Enzymatic Biosynthesis of Novel Resveratrol Glucoside and Glycoside Derivatives.” Appl Environ Microbiol. 2014, 80, 7235-7243.
183. Jha AK, Pokhrel AR, Chaudhary AK, Park SW, Cho WJ, Sohng JK “Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production.” Mol Cells. 2014 Oct 31;37(10):727-33.
184. Ghimire GP, Koirala N, Sohng JK. “Activation of cryptic hop genes from Streptomyces peucetius ATCC 27952 involved in hopanoid biosynthesis.” J Microbiol Biotechnol. 2015 May 28;25(5):658-61.
185. Dhakal D, Le TT, Pandey RP, Jha AK, Gurung R, Parajuli P, Pokhrel AR, Yoo JC, Sohng JK. “Enhanced Production of Nargenicin A1 and Generation of Novel Glycosylated Derivatives.” Appl Biochem Biotechnol. Appl Biochem Biotechnol. 2015 Mar;175(6):2934-49.
186. Romero A, Ruiz B, Sohng JK, Koirala N, Rodríguez-Sanoja R, Sánchez S. “Functional Analysis of the GlcP Promoter in Streptomyces peucetius var. caesius.” Appl Biochem Biotechnol. 2015 Mar;175(6):3207-17.
187. Ghimire GP, Koirala N, Pandey RP, Jung HJ, Sohng JK. “Modification of emodin and aloe-emodin by glycosylation in engineered Escherihia coli.” World J Microbiol Biotechnol. 2015 Apr;31(4):611-9.
188. Jha AK, Dhakal D, Van PT, Pokhrel AR, Yamaguchi T, Jung HJ, Yoon YJ, Sohng JK. “Structural modification of herboxidiene by substrate-flexible cytochrome P450 and glycosyltransferase.” Appl Microbiol Biotechnol. 2015 Apr;99(8):3421-31.
189. Chung MJ, Pandey RP, Choi JW, Sohng JK, Choi DJ, Park YI. “Inhibitory effects of kaempferol-3-O-rhamnoside on ovalbumin-induced lung inflammation in a mouse model of allergic asthma.” Int Immunopharmacol. 2015 Apr;25(2):302-10.
190. Jha AK, Paudel S, Dhakal D, Van PT, Ghimire GP, Sohng JK “Genetic evidence for the involvement of glycosyltransferase PdmQ and PdmS in biosynthesis of pradimicin from Actinomadura hibisca.” Microbiol Res. 2015 May;174:9-16.
191. Parajuli P, Pandey RP, Trang NT, Chaudhary AK, Sohng JK. “Synthetic sugar cassettes for the efficient production of flavonol glycosides in Escherichia coli.” Microb Cell Fact. 2015 Jun 9;14:76.
192. Jung HJ, Kim Y, Shin JY, Sohng JK, Kwon HJ. “Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α.” Arch Pharm Res. 2015 Jul 21.
193. Dhakal D, Sohng JK. ”Commentary: Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal” Frontiers in Microbiology July 2015. 6. 727.
194. Chaudhary AK, Pokhrel AR, Hue NT, Yoo JC, Sohng JK “Paired-termini Antisense RNA Mediated Inhibition of DoxR in Streptomyces peucetius ATCC 27952”Biotechnology and Bioprocess Engineernig 2015, 20, 381-388.
195. Pandey RP, Parajuli P, Chu LL, Darsandhari S, Sohng JK. “Biosynthesis of amino deoxy-sugar-conjugated flavonol glycosides byengineered Escherichia coli” Biochem Engineer J 2015 101: 191-199.